Kate:
There’s a paper that says that intense stress (first hit) produces vulnerability to depression in some cases (over 40%).  Those who were vulnerable  developed a depression-like phenotype after a second  hit of stress.

The vulnerability to depression resulted from “a persistent state of oxidative stress due to low brain-derived neurotrophic factor (BDNF) which controls the nuclear translocation of the master redox-sensitive transcription factor Nrf2, which activates antioxidant defenses.”

In other words, the antioxidant switch was turned off.

But instead of giving you what you need, they give you drugs that deplete nutrients. Both Elavil and Abilify can deplete coenzyme Q10 (CoQ10) which is an antioxidant. Elavil can deplete Vitamin B12 which, along with Folate is needed to be able to recycle homocysteine (which is toxic to neurons) and make SAMe which is needed to manufacture neurotransmitters.

SSRIs can deplete multiple nutrients, so we need to start looking at the things they deplete and how that affects different pathways. Otherwise people will continue being tortured.

So if asked again, “Are you a doctor? Did you go to medical school?” you can say….no, but I know that you don’t give drugs that deplete nutrients to somebody who’s already depleted.

But that is probably not all I would say.

Report comment

I was kept on one antipsychotic or another, as part of the so-called cocktail, for the next 10 years. Every time I objected, I was quickly silenced. Sometimes they said it was because of my anger. “We can’t handle your anger.”

Nobody thought about why I might be angry? Paying a psychiatrist for 6 years who only drugged me and didn’t keep any records? Being abused on a locked psych word while pregnant? Being made to see verbally and financially abusive outpatient therapists? Going broke paying for treatment that only brought me more problems? Being dropped by the psychiatrist I saw in high school who put me on Elavil in my first appointment and then dropped me without notice (or a phone number of somewhere to call if I had trouble) and didn’t even bother to tell me what to do about the Elavil? Begging for help for the next 3 years and only being mocked even when I attempted suicide with the Elavil? Being blamed for everything?

I had one psychiatrist who believed that Abilify fixed the “part of the brain that was broken in people BPD”. I saw her give a presentation at a conference about borderline at an Ivy League medical school where she attested to this “fact”.

Once when I went to see her for a med check, she said she needed to renew my Abilify prescription and asked me what dose I thought helped me the most. I said “I don’t think Abilify helps me at all.

She said, ” I’ve seen you off Abilify. I’m prescribing the highest dose”. Okay, I thought…then why did you ask? Now I know that I had akathisia that whole time — I think that’s what she was seeing and blaming it on me, on “the borderline”.

Everyone in the IOP DBT group was on one antipsychotic or another. Whenever they questioned it during diary card review, or if they admitted on their diary card that they had had an urge to skip their antipsychotic or that they had skipped their antipsychotic, which was a treatment interfering behavior, second in importance only to suicide, they would be humiliated by the clinicians.

“I don’t think I need it. I’m not psychotic. It’s making me ill”. Would be answered with, ” Are you a doctor? Did you go to medical school?”

No wonder psychiatric patients/survivors have so much anger. We were treated like lab rats and then blamed when the experiments done on us made us a bigger problem to people. We always got blamed.

Report comment

“spikes in brain histamine following stress likely drive neurochemical changes in monoaminergic systems. Indeed, elevated histamine can result in increased activation of H3 heteroreceptors on 5HT terminals in the hippocampus, resulting in blunting of neuronal serotonin release and producing a reduction in extracellular serotonin.”

Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318079/

Report comment

There’s a human pheromone, paternal reward pheromone, it’s the grease on any man’s face. You have to drive off the 74 or so volatiles sticking to it, I do it with dehydration, but I’m not completely sure it works, so there’s a risk of emotionally upsetting people. Get an IRB approval. Take a vehicle that absorbs lipids pretty well. I use ordinary new fresh un-chewed chewing gum, unleavened bred works well, too, and rub it on a healthy man’s face. You are picking up the face grease on his forehead, cheeks, chin, eyes, nose, lips, and neck. Dehydrate 95 F for 3 hours. Give it to the schizophrenic or drug addict, anxiety disordered person, personality disordered person, depressed person, attention/hyperactivity/obsessive-compulsive/post-traumatic stess disorders. Give about 10mg a day maximum. Monitor liver function tests. Follow with a half swallow of wine to rinse out the mouth to prevent osculation partners from getting jealous. Basically, it’s holy communion. Works great.

Report comment

A person will not understand something they are paid to not understand.

Report comment

Also, running a massive RCT with thousands of participants for two entire years would be prohibitive for many obvious reasons, like cost, time, and participant retention. It’s much more feasible to use existing data on 4000+ people followed for two years and factor in all the relevant confounding factors.

Report comment

I would argue that the onus is on those urging that antipsychotics be prescribed to prove that the drug is effective, especially when studies like this suggest that they are harmful.

Report comment

Report comment

People got worse. Many…especially the younger set…became demonstrably worse in the very ways that the pills are supposed to prevent.

My own personal problem with this study? I highly doubt many psychiatrists will listen. If they do listen it won’t affect their prescribing habits. And so…

Once again the information is available and straightforward. And once again most psychiatrists will continue on as usual because their toxic so called treatments are based more on dogma and current trends than data or anything remotely scientific.

Report comment

Report comment

What a novel insight.

Report comment

Well, as anyone who has actually, honestly, researched into psychopharmacology, with the goal of finding the truth, would know. Since both the antidepressants and antipsychotics are anticholinergic drugs, that can cause anticholinergic toxidrome poisoning … which can make a person “psychotic.”

https://en.wikipedia.org/wiki/Toxidrome

Of course, combining the anticholinergic drugs will make people worse.

Report comment

Report comment

Report comment

Short term psychosis: benzos are better according to patients, if anything is used at all.

Long term maintenance: prolongs symptoms, worsens people, causes brain damage/death

Report comment