Antidepressants

Post-SSRI sexual dysfunction (PSSD) may be a common adverse effect of antidepressants. Researchers are now attempting to understand the neurobiology behind it.

A new study promotes the use of a standardized approach to antidepressant tapering.

Combining drugs and therapy also did not lead to better depression outcomes than therapy alone.

Also, male mice born to mothers with an immune response exhibited “autistic-like” behaviors, scientists report.

A new study in rats found that those exposed to antidepressants in utero had an impaired ability to nurture their own children in later life.

A new literature review reinforces the need to “down-titrate” or taper antidepressants, especially drugs like Celexa and Paxil.

Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.

A study finds that commonly prescribed antidepressants are associated with the development of diabetes, hypertension, and other diseases.

Babies born to mothers taking antidepressants during pregnancy were more than six times as likely to have neonatal withdrawal syndrome—including breathing problems, irritability/agitation, tremors, feeding problems, and seizures—than those born to mothers taking other types of drugs.

Researchers can’t predict the 15% who benefit from antidepressants, and the other 85% are unnecessarily exposed to the harms of the drugs.

In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.

Researchers found that 25% of elderly patients taking antidepressants had serotonin syndrome, which is potentially life-threatening.

Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.

With the chemical imbalance theory falling out of fashion, researchers examine the claim that psychiatry never truly endorsed it.

A new study found that taking antidepressants did not improve quality of life.

According to patient reports, SSRI antidepressants most frequently lead to the subjective experience of emotional blunting.

A review of clinical practice guidelines for antidepressant discontinuation from across the English-speaking world reveals major pitfalls.

Researchers argue that we need a paradigm shift away from the biomedical model of mental illness to one informed by political action and common sense.

Antidepressant trials with negative results are still more likely than not to either be misleadingly spun as positive or unpublished.

A study in JAMA Neurology finds that antidepressants do not reduce depression symptoms more than placebo in patients recovering from a stroke.

A review of research on antidepressant efficacy finds that an unfavorable risk-to-benefit ratio.

A new research article asserts that the overuse of psychiatric drugs may create neurobiological changes that hamper long-term mental health recovery.

Meta-analysis finds that the placebo run-in methodology reduces the placebo effect and finds antidepressants to be less useful.

Leading researchers point out that a new antidepressant study in NEJM failed to account for withdrawal symptoms, casting doubt on the results.

In this podcast, we hear from the renowned clinician and researcher Dr. Giovanni Fava about his latest book entitled “Discontinuing Antidepressant Medications”.