Antidepressants No Better Than Placebo for About 85% of People

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Researchers can’t predict the 15% who benefit from antidepressants, and the other 85% are unnecessarily exposed to the harms of the drugs.

Surviving Antidepressants: An Interview with Adele Framer

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That is the truth about withdrawal syndrome: It’s like a 50-50 chance that you’re going to have a problem. If you’re in the unlucky half, you’re gonna be really unlucky.
3D render of placebo pills isolated over wood background

Placebo Effect—Not Antidepressants—Responsible for Depression Improvement

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In adolescent depression treatment, those who received a placebo but thought they received Prozac improved more than those who received the drug and knew it.

Antidepressants in Pregnancy: Risks to the Fetus and Long-term Health of the Child

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The research literature reveals that antidepressant use in pregnancy poses considerable risks to the fetus and the long-term health of the child. These risks include preterm birth, birth defects, abnormal brain development, and behavioral abnormalities in early childhood.

Antidepressant Use Linked to Sexual Dysfunction, Why Aren’t Prescribers Discussing It?

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Research sheds light on the impact of antidepressants on sexual dysfunction, emphasizing the need for patient-physician communication.

Suicide in the Age of Prozac

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During the past twenty years, the American Foundation for Suicide Prevention and American psychiatry have adopted a "medicalized" approach to preventing suicide, claiming that antidepressants are protective against suicide. Yet, the suicide rate in the United States has increased 30% since 2000, a time of rising usage of antidepressants. A review of studies of the effects of mental health treatment and antidepressants on suicide reveals why this medicalized approach has not only failed, but pushed suicide rates higher.

Newborn Babies Go Through Antidepressant Withdrawal

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A new study finds that newborn babies experience antidepressant withdrawal after birth if their mothers take SSRIs when pregnant.

Antidepressant Trials “Hijacked for Marketing Purposes,” Researchers Say

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About half of the large antidepressant trials are biased enough to be considered “seeding trials,” according to the researchers.

Hyperbolic Tapering off Antidepressants Limits Withdrawal

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New research by Jim van Os and Peter Groot finds that using hyperbolic tapering to discontinue antidepressants reduces withdrawal effects.

Stop Using Antidepressants Except for “the Most Severe Depression,” Experts Say

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Experts advocate limiting antidepressant use to only the most severe cases of depression, emphasizing the need for social and psychological interventions.

Antidepressant Use Tightly Correlates with Increased Suicide Rates

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While the study can’t confirm causality, it does contradict the notion that antidepressants reduce suicide at the population level.
VA Secretary Robert Wilkie

An Open Letter to VA Secretary Robert Wilkie: A Plan for Deprescribing Veteran Suicides

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Through my research and experiences, I've found that what the Veterans Administration has been doing to fight the veteran suicide epidemic isn't working and appears to be unintentionally exacerbating it. These problems are fixable. But I need your help.

Antidepressants Blunt Ability to Feel Empathy

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A new study suggests that taking antidepressants impairs empathy, while the experience of depression itself does not.

Stuart Shipko – SSRI Withdrawal: Shooting the Odds

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We interview Dr. Stuart Shipko, a psychiatrist and author who has a particular interest in the side effects and withdrawal effects of SSRI antidepressants and the need for informed consent when prescribing.

Suicide Rates Rise While Antidepressant Use Climbs

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Multiple media sources are reporting on new data from the CDC revealing a substantial increase in the suicide rate in the United States between 1999...

Antidepressant Use in Pregnancy Harms Child Development, Untreated Maternal Depression Shows Benefit

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In this new study, exposure to maternal anxiety in utero also harmed child development.

Common Side Effects Leading to Antidepressant Discontinuation

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New research finds the negative drug effects most commonly associated with initiating antidepressant discontinuation are anxiety, suicidal thoughts, vomiting, and rashes.

Antidepressant Exposure In Utero May Negatively Impact Motor Skills in 2-Year-Old Children

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A new study in Frontiers of Pharmacology finds that antidepressant use during pregnancy is linked to reduced motor skills in children at 2 years...
3D illustration of a matrix with tablets and the words risks and benefits. Concept of clinical trials results

Two Out of Three Find Antidepressant Effects Not Worth Burdens

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New study reveals: 2 in 3 people need more than the current antidepressant benefits to consider them worthwhile.
sertraline antidepressant withdrawal

Ambushed by Antidepressant Withdrawal: The Escape Story

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I’m alive. More than 30,000 veterans in the past decade alone are not. I was not warned of the risks of this drug. I was not told that once on it, I might never be able to get off it, or the nightmare that would ensue when I tried. I know millions of others were not told either.

Researchers Set the Record Straight on Controversial Zoloft Study

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An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).

How to Distinguish Antidepressant Withdrawal from Relapse

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Mark Horowitz and David Taylor provide advice on how to tell the difference between antidepressant withdrawal and depression relapse.

Overuse of Psychiatric Drugs is Worsening Public Mental Health, Doctor Argues

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A new research article asserts that the overuse of psychiatric drugs may create neurobiological changes that hamper long-term mental health recovery.

Antidepressants Do Not Prevent Suicides, May Increase Risk

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When the CDC released data revealing an increasing suicide rate in the US, some experts, speaking to major media outlets, speculated that the increase...

What Is the Risk of Permanent Sexual Dysfunction from Antidepressants?

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Males taking antidepressants were at 100 times the risk of erectile dysfunction compared with the healthy population and more than three times the risk even after controlling for other variables.